People affected by Parkinson’s illness and their households face a big selection of hardships and challenges. A latest research carried out by Neha Sharma (M. Pharm.) Assistant Professor and Dr. Navneet Khurana (M.Pharm., Ph.D.), Professor, School of Pharmaceutical Sciences, Lovely Professional University might open new doorways to the therapy and eventual remedy of this neurodegenerative illness. According to their findings, a cake or a pastry might do wonders for sufferers with Parkinson’s!
The duo together with different collaborators from different institutes examined the affect of vanillic acid or vanilla, a phytoconstituent, and a standard flavoring agent on Parkinson’s illness utilizing rat fashions.
“In the present study, we have tested the effect of vanillic acid for its possible effect on Parkinson’s disease using rats. We first induced Parkinson’s disease in rats using rotenone which is a pesticide known to induce this disease in rodents. After the successful development of this disease condition symptom in rats, the beneficial effect of vanillic acid was evaluated. We found that the acid successfully reversed the symptoms of Parkinson’s disease in rats,” the researchers acknowledged.
The duo additionally revealed that the end result was supported by the outcomes of histopathological and biochemical research in rats. It urged the doable useful impact of vanillic acid on Parkinson’s illness. According to the researchers, it took them three years to finish the analysis work.
“Parkinson’s disease is a muscle-related neurodegenerative disorder and there is a need for a promising and effective treatment for this devastating disease. The preclinical studies can be done to find out the molecular basis of its effect and after performing toxicity and safety studies on the vanillic acid, clinical trials can also be initiated after taking due approval from concerned authorities,” Neha Sharma (M. Pharm.) Assistant Professor and co-author of the research instructed Financial Express.com.
Parkinson’s illness is a progressive neurodegenerative illness and there’s no remedy for it but. As the illness progresses, sufferers discover it troublesome to even speak and take meals resulting from its devastating impact on the central nervous system. The accessible therapies are solely efficient in managing the long-term results of this illness and sufferers’ high quality of life.
“The current therapy for this devastating disease is managing only the symptoms and that is too for a short period of time. The benefits from the currently available drugs are quite limited at the later stages of this disease. As there is no safe and effective cure available, there is a real need for the development of effective therapeutic strategies which can deal with the underlying cause of this disease,” Sharma instructed Financial Express.com.
According to the researchers, vanillic acid may be transformed right into a pharmaceutical formulation which will assist sufferers with Parkinson’s illness. They consider that even every day consumption of this agent within the type of confectionery objects might also profit Parkinson’s illness sufferers.
“The compound tested in this study is of natural origin and showed good efficacy against Parkinson’s disease in an animal model. This research is quite useful in putting the light on this path of development of safe and effective therapeutic treatment for this disease,” Sharma instructed Financial Express.com.
The research additionally revealed that there’s a discount in oxidative stress stage parameters. As of now, no patents have been acquired but for this research. The research additionally proved that co-treatment of Vanillic acid and levodopa-carbidopa considerably protected the mind from neuronal injury resulting from oxidative stress and attenuated the motor defects indicating the doable therapeutic potential of VA as a neuroprotective in Parkinson’s illness.
“Ongoing Parkinson’s disease therapeutic interventions provide mainly symptomatic relief and have detrimental impacts on the patient’s routine life since they are used for a longer duration. Thus, our study gave hope to the Parkinson’s patients who may be able to use vanillic acid as a treatment with no or minimal side effects on their quality of life as this phytoconstituent has been reported to be ingested in daily life in different forms,” Sharma stated.
Source: www.financialexpress.com”